SLU-PP-332 [500mcg / 100ct]

Published research from the Burris lab and independent investigators has examined SLU-PP-332 across skeletal muscle, metabolic, and kidney tissue models. Billon and colleagues characterized SLU-PP-332's activation of an ERRα-dependent gene program overlapping the transcriptional signature of acute aerobic exercise, along with increased oxidative (type IIa) skeletal muscle fiber content, mitochondrial respiration, and treadmill running endurance in mice (2023). A follow-up study extended these findings to diet-induced obesity and ob/ob mouse models, reporting increased energy expenditure and fatty acid oxidation with decreased fat mass and improved insulin sensitivity (2024). A separate research group has also examined pan-ERR agonism in a mouse model of age-related kidney mitochondrial dysfunction (2023). All findings referenced here derive from preclinical rodent models and have not been validated in controlled human clinical trials.

· American Journal of Pathology